Don't Give Fleas a Biting Chance.®
Imagine relying on someone for your every need - your health, safety and happiness. Now imagine you are constantly itching and scratching. You are...infested with fleas! Millions of cats and dogs each year suffer from this problem. That's why Bayer Corporation created Advantage® (imidacloprid) Topical Solution, the fastest flea control.
With more than 150 million doses dispensed since 1996 and millions of flea-free pets, it's no wonder pet owners love Advantage®. Advantage® stops fleas from biting in three to five minutes, and starts killing fleas withing an hour. Within 12 hours of initial application, 98-100 percent of all existing fleas on pets are dead. For fast relief for your favorite furry friend, see your veterinarian and ask for Advantage® flea control.
Also try K9 Advantix®, flea, tick and mosquito treatment for dogs only to help keep those pesky parasites away.
Healthy pets are happy pets. You, as a pet owner, can feel confident that Advantage® (imidacloprid) Topical Solution works against fleas, fast.
Advantage® is the fastest topical solution, proven to stop fleas from biting in 3 - 5 minutes after application. Advantage kills 98-100 percent of fleas within 12 hours of initial application. In addition, one convenient treatment lasts for up to one month.
You don't need to use another flea control. Advantage® kills fleas before they lay eggs, so their life cycle is broken. And because it kills flea larvae within 20 minutes of contact, you don't need to use an insect growth regulator (IGR). Advantage also inhibits larval development in your pet's surroundings by more than 99 percent.
Cats and dogs are happy with how fast and easy Advantage® flea control is to use, and you will be too! Your veterinarian will determine the correct dosage for your pet by his/her weight. Once a month, the pre-measured dose is applied from an easy-to-use applicator tube. Advantage then spreads naturally on the surface of the pet's skin, with the help of movement by your cat or dog. In a matter of hours, the fleas are gone. It's as simple as that!

Advantage for Dogs
Applying Advantage® flea control on your caring canine is fast and easy. There are four package sizes (four- or six-packs) which offer flexibility in dosing:
- Puppies/Dogs 10 lbs. and under
- Puppies/Dogs 11-20 lbs.
- Puppies/Dogs 21-55 lbs.
- Dogs over 55 lbs.
Once you have the correct pre-measured dose from your veterinarian, follow the instructions below to provide your four-legged friend with fast relief:
To make your puppy or dog weighing up to 20 lbs. flea-free:
Use only on dogs. Do not use on other animals.
- Remove one applicator tube from the package.
- Hold applicator tube in an upright position. Pull cap off tube.
- Turn the cap around and place other end of cap back on tube.
- Twist cap to break seal, then remove cap from tube.
- The dog should be standing for easy application. Part the hair on the dog's back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube twice to expel the entire contents directly on the skin. Do not get this product in your pet's eyes or mouth.
- Discard empty tube by securely wrapping in several layers of newspaper and discarding in trash.

Advantage for Cats
Applying Advantage® flea control on your cat is fast and easy. There are two convenient package sizes (four- or six-packs) which offer flexibility in dosing:
- Kittens/Cats 9 lbs. and under
- Cats over 9 lbs
Once you have the correct pre-measured dose from your veterinarian, follow the instructions below to provide your purr-fect companion with fast relief.
To make your kitten or cat flea-free:
Use only on cats. Do not use on other animals.
- Remove one applicator tube from the package.
- Hold applicator tube in an upright position. Pull cap off tube.
- Turn the cap around and place other end of cap back on tube.
- Twist cap to break seal, then remove cap from tube.
- Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube twice to apply the solution directly on the skin. Do not get this product in your pet's eyes or mouth. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product.
- Discard empty tube by securely wrapping in several layers of newspaper and discarding in trash.

FAQ
Here are some answers to your most commonly asked questions about Advantage® (imidacloprid) Topical Solution. Remember to contact your veterinarian if you have more specific questions or if you are concerned with any other pet health issues. He or she can provide the best counsel to you.
Yes! Once a month, you simply apply a pre-measured dose from an easy-to-use applicator tube (your veterinarian will prescribe the dosage that's right for your pet). Just part the hair between the shoulder blades of your dog or on the back of the neck of your cat. Then apply the solution on your pet’s skin. That’s all there is to it.
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Yes. Bayer has always had the policy of selling Advantage only through licensed, practicing veterinarians with a doctor-client-patient relationship. It's even on our packaging. This is done to ensure you and your pet are getting the best counsel from the person who knows pets and their healthcare best -- your veterinarian.
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Advantage is proven to stop fleas from biting in 3 - 5 minutes1, providing the fastest relief. Fleas are killed within 12 hours of application. Re-infesting fleas start dying within one hour and all are killed within two hours.
1Mehlhorn, Heinz, The Mode of Action of Imidacloprid and a Comparison with other Insecticides (i.e., Fipronil and Selamectin) During In vivo and In vitro Experiments, Suppl. Compend. Contin. Educ. Pract. Vet., Vol. 22, No. 4A, 2000.
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Advantage is water-resistant. It continues to work even when your pet gets wet. Advantage works against fleas even after a shampooing, swimming or exposure to rain or sunlight.
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Yes, Advantage is so gentle it can be used on puppies as young as seven weeks and kittens as young as eight weeks.
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Yes, one of the most notable benefits of Advantage is that it is larvicidal. Flea larvae that lurk where your pet plays and sleeps are killed within 20 minutes after coming in contact with Advantage2. This larvicidal effect and the speed of kill of Advantage reduces the need for other environmental flea control products or growth inhibitors. It also inhibits larval development in the pet’s surroundings by greater than 99 percent3.
2Mehlhorn, H., Menke, H., Hansen, O., Effect of Imidacloprid on Adult and Larval Stages of the Flea Ctenocephalides felis after In vivo and In vitro Application, a Light- and Electron-microscopy Study, Parasitology Research, 85:625-637, 1999.
3Hopkins, T.J., Woodley, I., and Gyr, P. (1997) Imidacloprid Topical Formulation: Larvicidal Effect against Ctenocephalides felis in the Surroundings of Treated Dogs, Australian Veterinarian Practitioner, 1996, Vol. 26, p. 210.
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Early prevention is key to keeping pets from infestation. Starting a regular flea control regimen like Advantage before the beginning of flea season allows cats and dogs to be healthy and happy all year. Advantage alone can kill fleas and keep further populations from developing, because it effectively breaks the flea life cycle, attacking it in multiple stages. Fleas that jump onto an Advantage-treated pet start dying within one hour and all are killed within two hours.
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Once Advantage is applied to your pet, it spreads on the surface of the skin, aided by body movement, to provide whole body coverage. The revolutionary chemistry causes the flea's nervous system to become impaired, and the flea dies.
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Advantage is backed by extensive and thorough domestic animal safety studies that show even when administered at five times the target therapeutic dosage for three consecutive days, cats and dogs experienced no adverse effects4. If you apply as recommended, you can be confident of the gentleness of Advantage on your pet.
4Bayer Domestic Animal Safety Studies
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It is not necessary, but to obtain best results, it is recommended your pet be clean of excess dirt and debris, and be dry before applying Advantage.
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A single Advantage treatment will provide flea control for up to one month on cats and at least a month on dogs. The pet may be treated as often as once weekly, if necessary.
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Yes, Advantage can be used year-round as a preventative measure against flea infestation. It is especially beneficial in areas of the country where fleas are a more serious problem throughout the year. Just ask your veterinarian for more information.
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With Advantage, adult fleas are killed before they can lay eggs. In addition to killing adult fleas, Advantage also kills flea larvae. So when applied monthly, the flea life cycle is attacked at multiple critical stages, breaking the flea life cycle. Research shows when using Advantage, other environmental control products or insect growth inhibitors are not needed to control fleas. Advantage is all you need to keep your pet flea-free.
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As with any product, you should consult your veterinarian before using Advantage if your pet is pregnant or nursing.
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The successive feeding (biting) of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Secondary skin infections, tapeworms and even anemia are all medical problems associated with fleas. Most can become serious.
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Fleas will jump on your cat or dog, attracted by various stimuli such as body heat, movement and exhaled carbon dioxide. They bite to feed on the blood; then they produce eggs. Eggs drop from your pet to the ground or the carpet. The eggs develop into larvae and over time into adult fleas; then the life cycle starts all over again. A single flea can lay 20-25 eggs per day, so a "few" fleas can become "a lot" of fleas in a short time.
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Reinfesting fleas, which likely come from the pet's environment or outdoors, will be killed within two hours, with protection against further flea infestation lasting up to a month.
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It is the policy of Bayer Animal Health to sell Advantage only through licensed, practicing veterinarians. The reason for this is that we believe your veterinarian is most qualified to advise you on all aspects of your pet’s health, including flea control. For a FREE tube of Advantage from your veterinarian, click here.
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Yes. Simply "being wise with age" would not preclude the use of Advantage on a dog or cat. As with any product, pet owners with specific concerns should consult their veterinarian prior to use.
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Advantage was extensively tested on dogs and cats and found to be well tolerated even at exaggerated doses. Owners of exotic species should consult their veterinarian for appropriate methods of flea control.
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Advantage is available in packages of four and six applications. Both the four- and six-tube packages of Advantage are available in pre-measured, easy-to-use applicator tubes in two sizes for cats and kittens, and four sizes for dogs and puppies based on weight:
- Cats/Kittens up to 9 lbs.
- Cats over 9 lbs.
- Dogs/Puppies up to 10 lbs.
- Dogs/Puppies 11 - 20 lbs.
- Dogs/Puppies 21 - 55 lbs.
- Dogs over 55 lbs.
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Yes. Veterinary Pet Insurance covers costs for Advantage under the Vaccination & Routine Care Coverage insurance option. Click here for more information on Veterinary Pet Insurance.
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